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As a companion to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5[trademark]), the DSM-5[trademark] Guidebook serves two critical functions. First, it acts as a guide for busy clinicians in need of practical information on the use of diagnostic criteria and codes, documentation, and compensation. Second, it serves as an educational text and includes a structured curriculum that facilitates its use in courses and workshops. The guidebook demystifies DSM-5[trademark] and makes the content more accessible. The publication of DSM-5[trademark] has an enormous impact on every mental health professional, but especially clinicians, who need to know how to implement the diagnostic classification in their practices. The guidebook provides an entry point for clinicians, covering everything from coding changes to specific diagnoses to dimensional assessments. Practical and focused the DSM-5[trademark] Guidebook deserves its place next to DSM-5[trademark] in every clinician's office.