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Puns, anagrams, and palindromes are brought into play as Danny Yobar, a Spanish teacher at the Durham Friends School, and his father Stephen become embroiled in the colliding worlds of clinical research and the politics of sexual choice. In Research Triangle Park, North Carolina, fortunes are won and lost in the high stakes game of pharmaceutical research. As Alexandria Knotts monitoring company achieves success in a high tech HIV vaccine clinical trial, her business and private lives are at a cross-roads. Previous relationships threaten her new love life and Serious Adverse Events (SAEs) jeopardize the new-found success of her business.