President John F. Kennedys assassination is the most studied murder investigation of the 21st century, yet it remains plagued by questions and a variety of unproven theories. Regardless of how tenacious and believable an enduring claim may be, if lacking historical or scientific sustenance, it is a myth. While these intriguing, but unverifiable suppositions gather attention, they detract from the quality of information essential to explain this mysterious homicide. Myths are superficial, have no investigative depth and ask the reader to take a leap of faith that having supporting scientific evidence does not require. John F. Kennedy said, "The great enemy of truth is very often not the lie - deliberate, contrived and dishonest - but the myth, persistent, persuasive, and unrealistic." Filtering long held beliefs in the Kennedy assassination through contemporary, reliable, established scientific facts will help to dispel myths; the very thing Kennedy described as the great enemy of truth. Enemy of the Truth utilizes various forensic disciplines to dispel assassination mythologies, including simultaneous headshots, where the shooter for the fatal head shot was located, if the limousine stopped and more.