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This is the second of a two volume collection of seminal papers in the statistical sciences written during the past 100 years. These papers have each had an outstanding influence on the development of statistical theory and practice over the last century. Each paper is preceded by an introduction written by an authority in the field providing background information and assessing its influence. Readers will enjoy a fresh outlook on now well-established features of statistical techniques and philosophy by becoming acquainted with the ways they have been developed. It is hoped that some readers will be stimulated to study some of the references provided in the Introduction (and also in the papers themselves) and so attain a deeper background knowledge of the basis of their work.